Super Eagles star, Alex Iwobi played for 90 minutes in Everton’s 2-1 home defeat to Wolverhampton Wanderers at Goodison Park.
Iwobi however failed to add to his one goal so far this season for Everton albeit he found the net in three of his previous four matches in the league against Wolves.
The duo of Eberechi Eze and Michael Olise started at Selhurst Park as nine-man Crystal Palace were beaten 3-0 by Fulham.
At the King Power Stadium, Wilfred Ndidi and Kelechi Iheanacho were omitted from the starting line up for Leicester City but played the last 20 minutes of action as they welcomed high-flying Newcastle United.
Iheanacho and Ndidi then came off the bench in the 70th and 72nd minutes for Harvey Barnes and Boubakary Soumaré respectively.
Iheanacho wasted no time to attempt an effort on goal but the wide went agonizingly wide off target.
Joe Aribo came off the bench in place of Moussa Djenepo in Southampton’s 3-1 home defeat to Brighton & Hove at St Mary’s stadium just after the break.
The Nigerian international was however yellow-carded with an hour played for a harsh challenge on Pascal Gross.
Earlier in the day, Brentford played out a 2-2 draw with Tottenham Hotspur at the Gtech Community Stadium but Super Eagles midfielder, Frank Onyeka who has played 12 league games so far this season was not named in the squad.